00:00 right now 55 million americans use
00:03 and in canada marijuana dispensaries are
00:05 popping up everywhere like they're tim
00:08 and i in toronto can even order these
00:10 wittle thc drinks delivered to my front
00:12 door from the canadian government thanks
00:14 justin reed is being pitched to us is
00:17 amazing right well a recent survey found
00:19 that 4.3 percent of americans have tried
00:21 to quit marijuana at least
00:22 six times and failed plus now withdrawal
00:25 symptoms are being fully understood so
00:27 today we are going to explain
00:28 exactly what happens to your body when
00:30 you try to quit weed day one to two of
00:32 quitting is when withdrawal symptoms
00:35 meta-analysis of over 23 000 people
00:38 found that 47 had at least three of the
00:41 following withdrawal symptoms
00:43 nausea headaches depressed mood
00:45 difficulty getting to sleep
00:47 sweating anger nervousness decreased
00:55 now the risk of withdrawal symptoms is
00:57 proportional to the amount of marijuana
01:00 consuming for example someone who
01:02 consumed marijuana three times a week
01:05 less withdrawal symptoms than someone
01:07 who consumed marijuana every day
01:09 day three of quitting is when
01:10 irritability and anxiety peak
01:12 thankfully they begin to dissipate in
01:14 the coming days but on the other hand
01:16 the strange dreams and difficulty
01:18 getting to sleep only begin to
01:20 increase on day three this information
01:22 has led to new research
01:24 suggesting that chronic cannabis users
01:27 may induce intrinsic sleep problems
01:30 around day four of quitting is when the
01:31 amazing physiological changes in your
01:33 brain start to occur
01:35 marijuana contains molecules which mimic
01:37 natural neurotransmitters that are
01:39 already in your brain called
01:40 cannabinoids at baseline cannabinoids
01:43 circulate at lower quantities in your
01:45 but when you ingest marijuana you create
01:47 an influx of cannabinoids into your
01:50 most specifically an increase in the
01:52 psychoactive component thc aka delta 9
01:56 tetrahydrocannabinol
01:57 which is what i like to call it thc is
01:59 for noobs when i see someone with an
02:01 edible i say how much delta 9
02:03 tetrahydrocannabinol gotten there bud
02:04 the thc you've consumed while getting
02:08 the natural neurotransmitter anandamide
02:11 increased neuronal activity in certain
02:13 parts of your brain which cause
02:15 thoughts imagination and perception to
02:18 the thc binding to your neurons also
02:21 affects dopamine and norepinephrine
02:23 in the body which can lead to euphoria
02:27 and anxiety but the thing is as you
02:29 continue to consume weed it becomes
02:32 you start to create a desensitization
02:34 and down regulation
02:35 of your endocannabinoid receptors
02:38 specifically the cb1 receptor
02:40 since this receptor modulates systems of
02:44 increased cannabis use means a decrease
02:47 in short-term memory
02:48 thc also affects neurons involved in the
02:50 experience of novelty when thc binds
02:53 specific neurons the influx creates an
02:55 exciting sense of novelty
02:57 even for mundane repetitive tasks like
03:00 it's why you might get stoned and walk
03:02 down your same street and feel like
03:03 everything is heightened it's like
03:05 wow is everything in bloom it's the
03:07 middle of winter but regular cannabis
03:09 use leads to the down regulation of
03:11 these same neurons making it harder to
03:13 quit and making it harder to feel the
03:16 of a new experience while sober after
03:18 too much weed you might go to paris for
03:20 the first time and see the eiffel tower
03:22 and be like that's it
03:23 is it a lighthouse oh it's pointless
03:24 okay cool should we go up it no let's
03:26 not go up it uh we should just go home
03:27 but thankfully on day four of quitting
03:29 marijuana the cb1 cannabinoid receptors
03:32 will likely have returned to normal
03:34 functioning essentially it only takes
03:36 around four days of quitting marijuana
03:38 for the neuronal changes in your brain
03:40 to go back to baseline now this is new
03:42 research and i think it is important
03:44 that we continue to study this
03:46 as the popularity of weeds skyrockets we
03:48 need lots of long-term evidence about
03:50 how this could be affecting our brains
03:52 i am focusing on how the thc affects the
03:54 systems in your body how you get that
03:57 into you might involve smoking and the
03:59 act of smoking could have lasting
04:01 effects on your lungs but there is
04:02 actually a specific way that the thc in
04:05 your system can have
04:06 longer impacts on your neurology and
04:08 your brain if you consume too much
04:10 marijuana during development such as in
04:12 adolescence you can create long-term
04:15 neurophysiological effects
04:17 so yeah i started smoking weed in grade
04:20 10 which by definition is
04:21 adolescent so whoopsies as a closeted
04:25 in a high school with no other gay kids
04:27 i was sort of drawn to that stoner
04:29 skater crowd because to be honest they
04:31 were the most fashionable i also always
04:33 had this gay voice so when people come
04:34 up to me and be like
04:35 you're gay i'd be like actually no i'm
04:37 sort of like a quirky cool like
04:39 skater bro i'm avril lavigne but a boy
04:42 get it as a queer kid weirdly weed was
04:44 asset for me but all those reasons aside
04:47 scientific evidence now suggests that i
04:49 could have been doing long-term damage
04:51 to my neurophysiology so was it
04:54 worth it because when it comes to
04:55 marijuana's lasting neuronal effects
04:57 the age of your brain matters okay but
05:00 back to day five to seven of quitting
05:02 weed a recent study found most people
05:05 marijuana would fail on days five to
05:07 seven and it was hardest for people who
05:10 on marijuana marijuana dependence can be
05:12 defined as someone who has consumed
05:14 weed daily for 10 years and has
05:16 attempted to quit numerous times
05:18 but not made it past day 7. it can also
05:21 be defined by a continued use of
05:23 despite social psychological and
05:25 physical impairments
05:26 it should be noted that although many
05:28 scientists agree that marijuana
05:31 exist they also agree that dependence on
05:34 marijuana is less severe than dependence
05:37 cocaine or opiates but for marijuana
05:39 days five to seven are important days to
05:41 focus on when trying to quit as
05:44 they are the biggest hurdle i mean i
05:46 feel this i still consume weed yes it's
05:49 thankfully not daily but i do wonder if
05:52 and it is on day 5 to 7 where i usually
05:54 find myself ordering a little edible
05:56 from the gov gov and taking my just
05:58 dance skills to the next level it's also
05:59 honestly because the weekend comes
06:01 and i want to watch a movie stoned to be
06:03 honest in my adult ears i don't know if
06:04 i've ever entered a movie
06:06 theater not stoned for me movie theaters
06:08 represent the munchies and spending
06:10 79 000 on their largest popcorn also
06:13 chocolate to pour into the popcorn than
06:15 the gummies to eat to take the popcorn
06:17 out of my teeth while i'm eating the
06:19 and also nachos with an extra fake
06:21 cheese so i have enough fake cheese to
06:25 but finally if you make it to day 28 of
06:28 no weed all withdrawal symptoms
06:30 your affected endocannabinoid system and
06:34 receptors will return to baseline and
06:36 you might be able to understand a movie
06:38 so i'm not saying that you just have to
06:39 go out there and quit weed right now for
06:43 what i'm planning to do but i think it's
06:45 really important to understand what will
06:46 happen to you if you do decide to quit
06:48 life is hard and i do think that
06:49 education and learning is what allows
06:51 you to make the best choices for you and
06:53 i think science shows us that quitting
06:56 easy as we might think it is you can
06:58 click a link to our podcast where we
07:01 more about the science of quitting weed
07:03 make sure you're subscribed and we'll
07:04 see you next week for a new science